AI-Edigene? POLE p.L424I Reference Standard Plus
CBP10690
詢 價(jià)
索取COA
產(chǎn)品描述
產(chǎn)品數(shù)據(jù)庫(kù)
| Introduction | |
| Format | Genomic DNA |
| Description | POLE, DNA polymerase epsilon catalytic subunit, mediates proofreading activity during DNA repair and replication and plays a role in genomic stability. Somatic mutations in POLE have been identified in colorectal cancer, frequently in endometrial cancer, and are often associated with high tumor mutational burden, but are less likely to be associated with DNA mismatch repair (MMR) deficiency. |
| Technical Data | |
| DNA Change | c.1270C>A |
| AA Change | p.L424I |
| Mutation type | Substitution - Missense |
| Zygosity | Homozygous |
| Allelic Frequency | 100% |
| Transcript | NM_006231.4 |
| Cosmic ID | COSM937326 |
| Chr position(GRCh38) | chr12-132673664-G-T |
| Buffer | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |  |
| Storage | 2-8℃ |
| Expiry | 36 months from the date of manufacture |
