RXFP2 HEK293
CBP71621
| I. Background | |
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RXFP(Relaxin Family Peptide Receptor)家族是一類 G 蛋白偶聯(lián)受體,包含 RXFP1、 RXFP2、RXFP3 和 RXFP4 四個成員。RXFP2,又稱為 LGR8、GREAT,其蛋白質(zhì)結(jié)構(gòu)具有七次跨膜結(jié)構(gòu)域、胞外富亮氨酸重復序列以及一個低密度脂蛋白 A 類模塊,主要生理性配體為胰島素樣肽 3(INSL3)。 |
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| II. Description | |
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RXFP2 HEK293 細胞藥靶模型很好的模擬了體內(nèi) RXFP2 的信號轉(zhuǎn)導過程,原理見下圖所示。
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| III. Introduction | |
| Expressed gene: | RXFP2 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+2 μg/ml Puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Functional assay for RXFP2 |
| Transducer: | Gs |
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IV. Representative Data |
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