Mouse FCGR4 CHO
CBP74535
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產(chǎn)品描述
產(chǎn)品數(shù)據(jù)庫(kù)
| I. Background | |
| FCGR4 基因(CD16-2/FcγRIV)位于小鼠染色體 11q13.3,編碼低親和力 IgG Fc 受 體,對(duì) IgG2a/IgG2b 具有中等親和力,參與抗體依賴(lài)性細(xì)胞毒性(ADCC),在脾樹(shù)突狀細(xì)胞中促進(jìn)抗原呈遞,增強(qiáng) CD4+/CD8+ T 細(xì)胞免疫應(yīng)答,并介導(dǎo)中性粒細(xì)胞激活及破骨細(xì) 胞分化,影響骨吸收。該基因還與 IgE 結(jié)合,促進(jìn)巨噬細(xì)胞吞噬、T 細(xì)胞抗原呈遞及過(guò)敏反應(yīng)。此外,F(xiàn)CGR4 與動(dòng)脈粥樣硬化相關(guān),CVI 抗體可誘導(dǎo) Ly6a+Fcgr4+單核細(xì)胞增加,促進(jìn)斑塊消退。其功能機(jī)制涉及與 ITAM 信號(hào)亞基(如 FCER1G)形成復(fù)合物,激活 Src/Syk 激酶通路,調(diào)控免疫反應(yīng)及炎癥過(guò)程,在自身免疫性疾?。ㄈ?IgG4 相關(guān)疾?。┘?腫瘤治療中具有重要研究?jī)r(jià)值。 | |
| II. Description | |
| Mouse FCGR4 CHO 細(xì)胞,在 CHO-K1 細(xì)胞的基礎(chǔ)上,穩(wěn)定表達(dá)鼠 FCGR4。 | |
| III. Introduction | |
| Expressed gene: | Mouse FCGR4 |
| Host Cell: | CHO-K1 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | F12K+ 10% FBS + 5μg/ml Puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Binding Assay,FACS |
| IV. Representative Data | |
![]() Figure 1. Recombinant Mouse FCGR4 CHO constitutively expressing mouse FCGR4. |
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